Hi,
Throwing P0053, P0054 and P0443 codes. I cleared them and the CEL came right back on first time I drove it. Engine runs fine seemingly.

Also having transmission issues. Reverse is slipping, have to shift into low gear when at a stop bc I just rev in drive. O/d off light blinking. I have a feeling it's gonna need a rebuild...

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From the narrative and all information contained, the only thing I understand is you have an automatic transmission. The description would make me check the fluid level before condemning it as ruined. That's all I can say without more information.
I won't look up the meaning for codes and have not memorized them, but they might inform about the transmission. You can look them up, and then cut and paste the meanings into your posts so everyone else doesn't have to do that for you, or look them up themself, Unless they have them memorized.
tom